Recombinant Murine Noggin is a high-purity, animal-free recombinant protein expressed to mimic the biological activity of native mouse Noggin, a secreted antagonist of bone morphogenetic proteins (BMPs). Noggin plays a critical role in embryonic development and tissue patterning by binding BMPs and preventing receptor interaction, making it an essential tool for stem cell research, developmental biology, and regenerative medicine studies.
Determined by its ability to inhibit 10.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 2.9 - 4.3 ng/ml of Noggin.