Human NT3 (AF)

Recombinant NT-3, a neurotrophic factor, shares structural kinship with ?-NGF, BDNF, and NT-4, all part of the cysteine-knot family of growth factors known for their stable dimeric structures. It's predominantly expressed by neurons in the central nervous system and activates signaling pathways through the trk receptors. NT-3 plays a vital role in promoting the growth and survival of both nerve cells and glial cells. Notably, the amino acid sequences of Human, murine, and rat NT-3 are identical. Recombinant Human NT-3 forms a noncovalently linked homodimer consisting of two 13.6 kDa polypeptide monomers, totaling 240 amino acid residues.

Species	Human
Published species	Human, Mouse, Rat
Expression System	E. coli
Amino acid sequence	MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Molecular weight	27.2 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	The ED50 was determined by the dose-dependent stimulation of C6 cell proliferation and is ≤ 0.20 ng/mL, corresponding to a specific activity of ≥ 5 × 106 units/mg.
Conjugate	Unconjugated
Form	Lyophilized
Contains	no preservative
Storage conditions	-20°C

Code	Description	Pack Size
ZRP-NT3-2UG	Human NT3 (AF)	2ug
ZRP-NT3-10UG	Human NT3 (AF)	10ug
ZRP-NT3-100UG	Human NT3 (AF)	100ug
ZRP-NT3-500UG	Human NT3 (AF)	500ug
ZRP-NT3-1MG	Human NT3 (AF)	1mg

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