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Human GM-CSF (Animal-Free Recombinant)
Product Code: ZRP-GMCSF-250UG
CI ID: 6643
Pack Size: 250ug
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More Details
GM-CSF, a hematopoietic growth factor, plays a role in stimulating the development of neutrophils and macrophages while also supporting the proliferation and maturation of early erythroid, megakaryocytic, and eosinophilic progenitor cells. It's primarily produced in endothelial cells, monocytes, fibroblasts, and T-lymphocytes. GM-CSF has the additional effect of inhibiting neutrophil migration and boosting the functional activity of mature end cells. Unlike G-CSF, GM-CSF molecules are species-specific with no cross-reactivity between Human and murine versions. Recombinant Human GM-CSF is a 14.6 kDa globular protein comprising 128 amino acids, featuring two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
Specification
Species | Human |
Published species | Human, Mouse |
Expression System | E. coli |
Amino acid sequence | MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE |
Molecular weight | 14.6 kDa |
Class | Recombinant |
Type | Protein |
Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Endotoxin concentration | <0.1 EU/µg |
Activity | The ED50, determined by the dose-dependent stimulation of human TF-1 cell proliferation, is between 0.12 and 0.18 ng/ml. |
Conjugate | Unconjugated |
Form | Lyophilised |
Contains | no preservative |
Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.