Human PDGF-BB (AF)

PDGFs are dimers linked by disulfide bonds composed of two 12.0-13.5 kDa polypeptide chains known as PDGF-A and PDGF-B. Among the three naturally occurring PDGFs (PDGF-AA PDGF-BB and PDGF-AB) they act as potent mitogens for various cell types such as smooth muscle cells connective tissue cells bone and cartilage cells and certain blood cells. These growth factors are stored in platelet α-granules and are released during platelet activation contributing to processes like hyperplasia chemotaxis embryonic neuron development and respiratory tubule epithelial cell development. PDGFs interact with two distinct signaling receptors: PDGFR-α a high-affinity receptor for all three PDGF forms and PDGFR-β which specifically interacts with PDGF-BB and PDGF-AB. Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer consisting of two β chains totaling 218 amino acids.

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