Human IL-6 (AF)

IL-6 is a multifaceted cytokine pivotal in host defense, orchestrating immune and inflammatory responses. It's generated by T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, showcasing a wide array of biological functions. IL-6 promotes B cell differentiation and antibody production, collaborates with IL-3 in megakaryocyte development and platelet production, triggers the expression of hepatic acute-phase proteins, and governs bone metabolism.

Species	Human
Published species	Human, Mouse
Expression System	E. coli
Amino acid sequence	PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Molecular weight	20.9 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	Determined by its ability to stimulate the proliferation of mouse B9 cells. ED50 is 0.003 - 0.005 ng/ml, corresponding to a specific activity of ≥ 2.5 x 10^8 units/mg.
Conjugate	Unconjugated
Form	Lyophilized
Contains	no preservative
Storage conditions	-20°C

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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