Human IL-4 (AF)

IL-4 a multifaceted cytokine plays a crucial role in governing various T and B cell activities such as cell proliferation survival and gene expression. It is synthesized by mast cells T cells and bone marrow stromal cells. IL-4 specifically directs the transformation of naive CD4+ T cells into helper Th2 cells known for their cytokine-secretion profile that includes IL-4 IL-5 IL-6 IL-10 and IL-13 all conducive to a humoral immune response. Additionally IL-4 is pivotal in regulating the shift of immunoglobulin classes towards IgG1 and IgE isotypes. An important note is that excessive IL-4 production by Th2 cells can lead to heightened IgE production and allergic responses. The recombinant Human IL-4 a 15.1 kDa globular protein containing 130 amino acid residues mirrors these regulatory functions in the immune system.

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