Human VEGF 165 (AF)

VEGF stands out as a potent cytokine driving growth and angiogenesis. It fosters endothelial cell proliferation and survival contributing significantly to angiogenesis and vascular permeability. Its expression in vascularized tissues plays a crucial role in both normal and abnormal angiogenesis. VEGF's involvement is notable in tumor metastasis induction and intraocular neovascular syndromes. VEGF signals through three receptors: fms-like tyrosine kinase (flt-1) the KDR gene product (with the murine equivalent being the flk-1 gene product) and the flt4 gene product. Recombinant Human VEGF165 is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Species	Human Mouse Rat
Published species	Human Mouse Rat
Expression System	E. coli
Amino acid sequence	GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Molecular weight	26 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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