Human VEGF 165 (AF)

VEGF stands out as a potent cytokine, driving growth and angiogenesis. It fosters endothelial cell proliferation and survival, contributing significantly to angiogenesis and vascular permeability. Its expression in vascularized tissues plays a crucial role in both normal and abnormal angiogenesis. VEGF's involvement is notable in tumor metastasis induction and intraocular neovascular syndromes. VEGF signals through three receptors: fms-like tyrosine kinase (flt-1), the KDR gene product (with the murine equivalent being the flk-1 gene product), and the flt4 gene product. Recombinant Human VEGF165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Published species	Bovine, Chicken, Dog, Fish, Hamster, Horse, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Sheep
Expression System	E. coli
Amino acid sequence	APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Molecular weight	38.2 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage	-20°C

 

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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