Human M-CSF (AF)

M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their progenitor cells. Notably, M-CSF plays significant roles in modulating dermal thickness and fertility. Clinically, it finds use in treating infections, malignancies, and atherosclerosis, aiding hematopoietic recovery post bone marrow transplantation. While Human M-CSF is reactive in murine systems, the murine molecule lacks activity on Human cells. Recombinant Human M-CSF is a homodimeric protein weighing 36.8 kDa, composed of two 159 amino acid polypeptide subunits.

Species	Human
Published species	Human, Mouse, Rat
Expression System	E. coli
Amino acid sequence	MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS
Molecular weight	36.8 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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