Human IL-4 (AF)

IL-4, a multifaceted cytokine, plays a crucial role in governing various T and B cell activities such as cell proliferation, survival, and gene expression. It is synthesized by mast cells, T cells, and bone marrow stromal cells. IL-4 specifically directs the transformation of naive CD4+ T cells into helper Th2 cells, known for their cytokine-secretion profile that includes IL-4, IL-5, IL-6, IL-10, and IL-13, all conducive to a humoral immune response. Additionally, IL-4 is pivotal in regulating the shift of immunoglobulin classes towards IgG1 and IgE isotypes. An important note is that excessive IL-4 production by Th2 cells can lead to heightened IgE production and allergic responses. The recombinant Human IL-4, a 15.1 kDa globular protein containing 130 amino acid residues, mirrors these regulatory functions in the immune system.

Species	Human
Published species	Human, Mouse
Expression System	E. coli
Amino acid sequence	MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Molecular weight	15.1 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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