Human IL-3 (AF)

IL-3 acts as a crucial hematopoietic growth factor, supporting the survival, differentiation, and proliferation of specialized progenitor cells spanning various lineages such as megakaryocytes, granulocyte-macrophages, erythrocytes, eosinophils, basophils, and mast cells. It is produced by T cells, mast cells, and eosinophils, contributing significantly to processes like thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. IL-3 also triggers monocyte activation, suggesting potential additional roles in immunoregulation. Many of its effects hinge on co-stimulation with other cytokines. Notably, IL-3 shows species-specific variability in glycosylation patterns. The recombinant Human IL-3 is a 15.0 kDa globular protein comprising 133 amino acid residues.

Species	Human
Published species	Human, Mouse
Expression System	E. coli
Amino acid sequence	APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF
Molecular weight	15 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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