Human BMP-4 (AF)

Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily, a group of structurally related signaling proteins. This superfamily is widely distributed in the body and plays diverse roles during prenatal and postnatal life. Like BMP-7, BMP-4 contributes significantly to bone and cartilage development and maintenance. Reduced BMP-4 expression is linked to various bone disorders, including Fibrodysplasia Ossificans Progressiva, an inherited condition. E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, corresponding to amino acids 303-408 of the full-length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.

Species	Human
Published species	Human, Mouse, Rat
Expression System	E.Coli
Amino acid sequence	KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Molecular weight	23.9 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
Conjugate	Unconjugated
Form	Lyophilised
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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