Human BMP-2 (AF)

Bone Morphogenetic Proteins (BMPs) are part of the TGF-β superfamily, a group of structurally related signaling proteins. Among them, BMP-2 stands out as a potent osteoinductive cytokine, capable of prompting bone and cartilage formation when coupled with osteoconductive carriers like collagen and synthetic hydroxyapatite. Besides its role in osteogenesis, BMP-2 contributes significantly to cardiac morphogenesis and is expressed in various tissues such as the lung, spleen, brain, liver, prostate, ovary, and small intestine. The active form of BMP-2 is a 26 kDa protein made up of two identical 114 amino acid polypeptide chains connected by a single disulfide bond. Each BMP-2 monomer is part of a precursor polypeptide, featuring a 23 amino acid signal sequence for secretion and a 259 amino acid propeptide. Upon precursor dimerization, a furin-type protease cleaves the covalent bonds between the propeptide (also a disulfide-linked homodimer) and the mature BMP-2 ligand. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein composed of two 115 amino acid polypeptide chains.

Species	Human, Mouse, Rat
Published species	Human, Mouse
Expression System	E. coli
Amino acid sequence	MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Molecular weight	26 kDa
Class	Recombinant
Type	Protein
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration	<0.1 EU/µg
Activity	Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml.
Conjugate	Unconjugated
Form	Lyophilised
Purification	HPLC, SDS-PAGE
Contains	no preservative
Storage conditions	-20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.

Biomanufacturing

Research

Regenerative Medicine

Stem Cell Research

Tissue Engineering

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